WHAT ARE PLATELETS?

Simply put, your blood has a lot of tiny things called platelets. They help in clotting your blood, which means that if you get a cut, some of your platelets stick together to plug the hole in the blood vessel wall caused by the cut. Eventually, the clot dries out to protect the healing skin underneath. They are your microscopic guardian angels.

Plasma, on the other hand, is the colorless fluid part of blood, lymph, or milk, in which fat globules are suspended.

PLATELET RICH PLASMA THERAPY

Even though blood is chiefly a fluid called plasma, it also contains small solid components (red cells, white cells, and platelets.) The platelets are known for their significance in coagulating blood. Be that as it may, platelets additionally contain many proteins called growth factors which are essential in the healing of wounds.

To build up a PRP planning, blood should initially be drawn from a patient. The platelets are isolated from other platelets and their focus is expanded amid a procedure called centrifugation. PRP for skin is generally prepared by a process known as “differential centrifugation”. In differential centrifugation, acceleration force is adjusted to sediment certain cellular constituents based on different specific gravity. Which is to say, the force applied in this method of coagulation of blood is adjusted so as to coagulate only the desired materials from the blood.

PRP (Platelet Rich Plasma) is a biological product characterized as a bit of the plasma portion of blood with a platelet concentration which is over the standard before its centrifugation. PRP contains an exceedingly high level of platelets as well as the full supplement of clotting factors, the latter regularly staying at their normal physiologic dimensions. It is advanced by a scope of GFs, chemokines, cytokines, and other plasma proteins.

The PRP is acquired from the blood of patients before centrifugation. After centrifugation and as indicated by their diverse thickness inclinations, the partition of blood segments (red platelets, Platelet Rich Plasma [PRP], and Platelet-Poor Plasma [PPP]) pursues. At that point, the expanded convergence of platelets is joined with the rest of the blood.

ARE THERE ANY SIDE EFFECTS OF PRP THERAPY?

As injecting PRP includes utilizing an individual’s own platelets, they don’t really have any sort of adverse effects on the individuals. It is essentially just taking something from your own body, and then putting it right back, but concentrated at a single place. In any case, it is still possible that an individual may have irritation or pain related with the site of the injection, which is completely normal.

A great many people can continue their typical daily activities very quickly subsequent to having a PRP infusion. The normal time from blood-drawing to the PRP injection itself is only about 30 minutes.

TREATMENTS DONE THROUGH PRP THERAPY

1. HAIR GROWTH

To reduce the inflammation caused in the scalp, a PRP is injected so hair loss takes place.

In 2015 in the journal Stem Cells Translational Medicine, which found that men receiving PRP treatment grew more hair and with significantly more density than men who did not. However, the treatment was on 20 individuals only, so it was a small-scale study. ^[1]

PRP treatment for hair diminishing, loss and thinning has turned out to be the new instrument accessible. At the point when PRP is utilized for hair rebuilding and restoration, the growth factors and microorganisms cooperate to invert the scaling down of the hair follicle, kicking off the torpid hair once more into the growth stage. Hair development is stimulated.

2. TISSUE MENDING

 

Platelet-rich plasma treatment for plastic surgery procedure.

Platelet-rich plasma treatment might be utilized in plastic surgery procedure to advance tissue mending. Doctors and specialists initially utilized PRP to help individuals recuperate after jaw and plastic procedures.

Examples of tissues that PRP has been utilized on include:

• Ligaments
• Tendons
• Muscles

Ligaments can require some serious energy and be hard to mend, which can influence PRP an appealing choice for a portion of the individuals to have encountered wounds to this tissue gathering.

Why do we require PRP for skin?

While discussing the various aspects ageing skin, the main objective is to keep your skin from the breakdown of collagen.

What is collagen? Collagen is the most abundant protein in your body. It is the major component of connective tissues that make up several body parts, including tendons, ligaments, skin and muscles. Collagen has many important functions, including providing your skin with structure and strengthening your bones. At the point when collagen breakdown of your skin begins, indications of ageing start to appear. Our answer is, PRP for skin!

Grounded collagen, through PRP, results in more tight, toned, smoother skin. Presenting growth factors at a more profound level of the skin, harmed cells, and reinforcing collagen as it recharges itself.

ADVANTAGES OF PRP THERAPY

PRP Therapy can benefit most individuals and can be used to treat a variety of aging concerns, including but not limited to:

• Facial Ageing
• Fine Lines
• Hair Thinning
• Uneven Skin Tone
• Acne Scars

Response to such treatments is different from person to person. An analysis of skin is a pre-requisite to plan the course of treatment and to review the progress.

TYPES OF TREATMENTS:^[3]

Some of the most common types of PRP therapies include:

• Micro needling with PRP:

During this treatment, PRP is painted onto face and then a tool is used to make micro-wounds on skin that heal rapidly tightening and rejuvenating skin.

• PRP Injection Therapy:

PRP is injected into skin to encourage collagen growth within the skin. It is particularly effective in reducing acne scarring, wrinkles and lip lines.

• Micro needling with PRP Injections

This treatment combines injections with micro needling, to treat skin cells on the inside and the outside.

WHO ALL CAN UNDERGO PRP THERAPY?

An effective treatment for both men and women, most patients of all ages can benefit from PRP injection therapy. The reason for this is simple. Platelet-rich plasma is derived from a patient’s own blood, as told above, and hence making it completely biocompatible which leaves no room for any allergic reaction.

PRP injections do not carry the adverse side effects of other treatment options. Because of the safety factor, PRP therapy is becoming a popular rejuvenation option for those who are showing early to moderate signs of aging. ^[4]

However, be sure to report all medications you’re on before the procedure including supplements and herbs ^[5]. When you go for your initial consultation.

CONCLUSION

The utility of PRP is increasing in the field of dermatology and aesthetics. Though commercially marketed PRP systems offer ready-to-apply platelet-rich suspensions in a sterile manner, high cost, limited volume of drawn blood, differences in centrifugation guidelines, wide variation in platelet concentration, makes it difficult for the clinician to choose amongst the readily available PRP kits. ^[6]

PRP therapy is a simple, very cost-effective and feasible treatment option for treatment of hair loss and facial rejuvenation can be regarded as an effective and valuable treatment modality. Although PRP has sufficient theoretical scientific basis to support its use in hair restoration, hair restoration using PRP is still at its infancy. While the clinical evidence is still weak, considering its excellent safety profile and relatively low cost, PRP hair treatment is a promising treatment option!

Citations:

1. BENEFITS IN HAIR GROWTH (https://www.medicalnewstoday.com/articles/320107.php?fbclid=IwAR3X6VxBAmKz4DZTh1tSx7tQKwfyp2AXp8JUmp1RslTaS4M_cSJ47Ed7RYY)
2. Stem Cells Translational Medicine (https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.5966/sctm.2015-0107)
3. VARIOUS TREATMENTS FOR SKIN (http://youthcorridorclinic.com/prp/?gclid=Cj0KCQjw4qvlBRDiARIsAHme6osNP1irLfd8q78Ey43kcouclMv7mK_4kD1G3vHgjgn0Ikqc2jicw3kaAgboEALw_wcB&fbclid=IwAR0ebXMBxQ756-Gc9bMslkiocA4rezn4Ertc7sBiFZusfWK_dbljqX-fiQE)
4. IDEAL CANDIDATES FOR PRP THERAPY (https://goldenbergdermatology.com/platelet-rich-plasma-prp-treatments-in-new-york-city/?fbclid=IwAR0_tfBixiMkc8Vw0MRoALJd7RQXY-2iF_flP2Ig3LexMI96hQIjizMadnY)
5. RISKS OF PRP FOR HAIR LOSS (https://www.healthline.com/health/prp-for-hair-loss#risks)
6. PRINCIPLES AND METHODS OF PREPARATION OF PLATELET-RICH PLASMA (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338460/)